Many studies done to date link QoL to the presence and severity of HIV-related symptoms in PWAs. The strongest predictors of poorer QoL in HIV-infected persons are the presence of disease-related symptoms and advancing stage of disease.63-65 Intravenous drug abuse and lower education level have been associated with lower reported function in all areas.63 Constitutional complaints such as fatigue, fevers, and weight loss, as well as neurological symptoms, have the greatest overall negative impact on health status. Chronic diarrhea has a serious adverse effect on role func-tion, whereas dyspnea interferes more with physical than role function