Dipic and Met play as chelating ligands in the PdII metal
complex. Upon complexation of (MetH)2(dipic) proton transfer
compound with PdCl2, suitable crystals for X-ray are prepared.
From the chemical structure of the resulting complex it may be
concluded that other mix metal complexes involving metformin
and dipicolinic acid could be prepared following the same strategy.
Considering the previously reported biological activities of Cobalt
and Vanadium complexes of pyridinedicarboxylic acids, and
oxovanadium metformin complexes, the vanadium complex of
(MetH)2(dipic) possibly could benefit the presence of dipic, Vanadium and Met simultaneously in a single compound. This could improve the potential and possible synergy of vanadium complexes.
It seems to us that there is a significant potential for further
development of these complexes as insulin-mimic compounds.