Anjana Fuangchan (2010, P.68) Hypoglycemic effect of bitter melon in patients with type 2 diabetes. The retrospective study on the eight year usage of bitter melon at Dansai Crown Prince Hospital suggested that bitter melon may be a useful adjunctive treatment for patients with mildly to moderately uncontrolled diabetes. However, prospective double-blind, placebo or active-controlled trials with long-term follow-up and using a standardized dosage formulation are needed before the routine use of bitter melon can be advocated. Regarding RCT, dried powder of fruit pulps of bitter melon exhibited a hypoglycemic effect, but less than that of metformin. The 2,000 mg/day of dried powder of bitter melon showed maximum hypoglycemic effect compared with other doses.
Komsit Sathapanapitukkij (2011, P.29) Circulation levels of lipid hydroperoxide, malondialdehyde and total antioxidant measurement in type 2 diabetes patients. Source of oxidative stress in diabetes include an increased production of free radical, especially from glycation and lipid peroxidation process, and decreased antioxidant defense systems as the results of this study. The oxidative stress biomarkers, lipid hydroperoxide and malondialdehyde, from lipid peroxidation process in patients with type 2 diabetic patients were increased compared with healthy control. This results indicated that patients with type 2 diabetes mellitus had increased oxidative stress status and total antioxidant capacity in type 2 diabetic patients were decreased this may be cause by the counter action for the oxidative stress in type 2 diabetic patients. The oxidative stress biomarker (lipid hydroperoxide and malondialdehyde) and total antioxidant capacity were used as biomarkers for prognosticate in the development of atherosclerosis and/or cardiovascular complication in diabetic patients.
Anjana Fuangchan (2010, P.68) Hypoglycemic effect of bitter melon in patients with type 2 diabetes. The retrospective study on the eight year usage of bitter melon at Dansai Crown Prince Hospital suggested that bitter melon may be a useful adjunctive treatment for patients with mildly to moderately uncontrolled diabetes. However, prospective double-blind, placebo or active-controlled trials with long-term follow-up and using a standardized dosage formulation are needed before the routine use of bitter melon can be advocated. Regarding RCT, dried powder of fruit pulps of bitter melon exhibited a hypoglycemic effect, but less than that of metformin. The 2,000 mg/day of dried powder of bitter melon showed maximum hypoglycemic effect compared with other doses.
Komsit Sathapanapitukkij (2011, P.29) Circulation levels of lipid hydroperoxide, malondialdehyde and total antioxidant measurement in type 2 diabetes patients. Source of oxidative stress in diabetes include an increased production of free radical, especially from glycation and lipid peroxidation process, and decreased antioxidant defense systems as the results of this study. The oxidative stress biomarkers, lipid hydroperoxide and malondialdehyde, from lipid peroxidation process in patients with type 2 diabetic patients were increased compared with healthy control. This results indicated that patients with type 2 diabetes mellitus had increased oxidative stress status and total antioxidant capacity in type 2 diabetic patients were decreased this may be cause by the counter action for the oxidative stress in type 2 diabetic patients. The oxidative stress biomarker (lipid hydroperoxide and malondialdehyde) and total antioxidant capacity were used as biomarkers for prognosticate in the development of atherosclerosis and/or cardiovascular complication in diabetic patients.
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