A recent meta-analysis of 82 randomized controlled studies detected a statistically significant reduction in AAD when probiotics were used concomitantly during the administration of antibiotics.
However, the studies[8-14] were extremely heterogeneous in terms of their patient population and use of probiotics and antibiotics. Although cultures of lactobacillus[15] were used in the majority of the studies, the bacterial strains were poorly defined and characterized. Clear evidence for a standardized adjuvant probiotic administration could not be formulated, although more than 11000 patients were included in these studies[16].
Another meta-analysis found a statistically significant advantage for lactobacillus strain probiotics; however, there was significant heterogeneity in the study design (study population, probiotic used, definition of AAD, dose and duration of probiotic administration)[17].
In a systematic review, four out of six studies of the highest quality supported an effect of probiotics against AAD[18].
A recent meta-analysis of 82 randomized controlled studies detected a statistically significant reduction in AAD when probiotics were used concomitantly during the administration of antibiotics.
However, the studies[8-14] were extremely heterogeneous in terms of their patient population and use of probiotics and antibiotics. Although cultures of lactobacillus[15] were used in the majority of the studies, the bacterial strains were poorly defined and characterized. Clear evidence for a standardized adjuvant probiotic administration could not be formulated, although more than 11000 patients were included in these studies[16].
Another meta-analysis found a statistically significant advantage for lactobacillus strain probiotics; however, there was significant heterogeneity in the study design (study population, probiotic used, definition of AAD, dose and duration of probiotic administration)[17].
In a systematic review, four out of six studies of the highest quality supported an effect of probiotics against AAD[18].
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