Results: Of the newly treated AD patients, the proportion of rivastigmine and
donepezil patients who continued their medication was the same (47%; p = 0.5).
On average, rivastigmine users continuously used their medication for 234 days
(median 312 days) while those taking donepezil used their medication for 235
days (median 315 days) [p = 0.91]. Patients were more likely to discontinue or
switch their initial cholinesterase inhibitor if they used a central nervous system
(CNS) medication before initiation of therapy (relative risk [RR] = 1.23; 95% CI
1.01, 1.51 without adjustment for study variables; RR = 1.30; 95% CI 1.05, 1.60
with adjustment for study variables).On the other hand, patients were less likely
to discontinue their cholinesterase inhibitor if they visited their physician office
frequently (RR = 0.24; 95% CI 0.18, 0.32 without adjustment; RR = 0.23; 95% CI
0.17, 0.30 with adjustment)or if they were hospitalised after initiation of their
cholinesterase inhibitor therapy
Results: Of the newly treated AD patients, the proportion of rivastigmine and
donepezil patients who continued their medication was the same (47%; p = 0.5).
On average, rivastigmine users continuously used their medication for 234 days
(median 312 days) while those taking donepezil used their medication for 235
days (median 315 days) [p = 0.91]. Patients were more likely to discontinue or
switch their initial cholinesterase inhibitor if they used a central nervous system
(CNS) medication before initiation of therapy (relative risk [RR] = 1.23; 95% CI
1.01, 1.51 without adjustment for study variables; RR = 1.30; 95% CI 1.05, 1.60
with adjustment for study variables).On the other hand, patients were less likely
to discontinue their cholinesterase inhibitor if they visited their physician office
frequently (RR = 0.24; 95% CI 0.18, 0.32 without adjustment; RR = 0.23; 95% CI
0.17, 0.30 with adjustment)or if they were hospitalised after initiation of their
cholinesterase inhibitor therapy
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