Nishimura et al. reported that probucol might
prevent the progression of early stage of diabetic
nephropathy [26]. In the present study, increase of
urinary protein was significantly suppressed and
increase of serum creatinine tended to be suppressed
in the probucol group comparing to non-probucol
group (Table 3). In advanced cases, increases of both
serum creatinine and urinary protein were signifi-
cantly suppressed in the probucol group compared to
non-probucol group (Table 3). These results suggest
that probucol may prevent the progression of not only
early stage but also overt nephropathy and advanced
stage diabetic nephropathy.