Vaccination is the administration of antigenic material to stimulate an individual is immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection . The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases, widespread immunity due to vaccination is largely responsible for the worldwide of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world.