A study from Thailand carried out by Pinsornsak and Niempoog36 in 2012 performed a randomized control trial of the efficacy of 1,000 mg/day of C. longa extract as an adjuvant therapy of diclofenac (75 mg/day) for 3 months in 88 primary knees with OA. They found no statistical significance between groups in visual analog scale for pain and functions evaluated by Knee Injury and Osteoarthritis Outcome Score.37 That means that C. longa extract does not add more benefit for subjects than those receiving only diclofenac.