Antioxidant activity of polyphenols may have health-promoting and disease-preventing effects. Consequently, consumption of eggplant, which contains polyphenols, or extracts of polyphenols from eggplant, may have a potential therapeutic use. Our study confirms that polyphenols are present in various parts of eggplant, in particular skin, suggesting the use of the entire vegetable as food; MAE may be an attractive alternative to conventional method to improve the amount of polyphenols extracted, in particular for nutraceutical application. Extraction of skin with 50% aqueous ethanol with microwave irradiation was particularly effective. In addition, our study provides evidence that EPS50MAE exhibits interesting antioxidant properties, expressed by its capacity to scavenge superoxide anion and to inhibit lipid peroxidation.