Currently, Health food products are most popular due to it is the choice for health care people. Health problems from food consumption, lifestyle changes and environment stress effect results to many diseases such as cancer, heart disease, high blood pressure, diabetes etc. The natural foods are one choice of the consumers because it contains the important nutrients and bioactive compounds, such as phenolic compound, gamma oryzanol and vitamin E. One of the important compounds which present in many plants food is melatonin, related with the characteristic circadian rhythm, jet lag, sleep disorder and shift workers, who often complain of fatigue, sleep disturbances etc.