Abstract
Conclusion: The meta-analysis supported the proposition that the prevalence of gastroesophageal reflux disease (GERD) was
associated with laryngeal cancer, particularly in the hospital-based control group and diagnosed by esophagogastroduodenoscopy
(EGD) or esophageal pH monitoring. However, no significant association was found between GERD and pharyngeal
carcinoma. Objectives: A number of studies have been conducted to investigate the relationship between gastroesophageal
reflux and laryngeal or pharyngeal carcinoma. The conclusions are still debated. Methods: We conducted a systematic review
of studies associated with the prevalence of GERD in laryngeal or pharyngeal cancer, published up to November 2013.
Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random effects models or
fixed effects models, according to heterogeneity I2
. Results: Ten studies were included in this meta-analysis. On average,
GERD was significantly higher in the tumor tissue of the study group compared with normal tissue of the control group
(OR = 2.17, 95% CI = 1.50, 3.14; random effects analysis). The pooled ORs for laryngeal carcinoma were 2.21 (95%
CI = 1.53–3.19; I2 = 97, random effects model) and 3.76 (95% CI = 0.21–67.48; I2 = 94, random effects model) for pharyngeal
carcinoma
AbstractConclusion: The meta-analysis supported the proposition that the prevalence of gastroesophageal reflux disease (GERD) wasassociated with laryngeal cancer, particularly in the hospital-based control group and diagnosed by esophagogastroduodenoscopy(EGD) or esophageal pH monitoring. However, no significant association was found between GERD and pharyngealcarcinoma. Objectives: A number of studies have been conducted to investigate the relationship between gastroesophagealreflux and laryngeal or pharyngeal carcinoma. The conclusions are still debated. Methods: We conducted a systematic reviewof studies associated with the prevalence of GERD in laryngeal or pharyngeal cancer, published up to November 2013.Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random effects models orfixed effects models, according to heterogeneity I2. Results: Ten studies were included in this meta-analysis. On average,GERD was significantly higher in the tumor tissue of the study group compared with normal tissue of the control group(OR = 2.17, 95% CI = 1.50, 3.14; random effects analysis). The pooled ORs for laryngeal carcinoma were 2.21 (95%CI = 1.53–3.19; I2 = 97, random effects model) and 3.76 (95% CI = 0.21–67.48; I2 = 94, random effects model) for pharyngealcarcinoma
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