Preclinical work suggests that Bacopa’s mechanisms of action on the central nervous system are varied and include antioxidant activity (across various Bacopa extracts), b-amyloid scavenging properties (Bacopa ethanol extract: 40 or 160 mg/kg orally), protection against bamyloid-induced cell death (Bacopa ethanol extract administered to cultured neurons),modulation of frontocortical and
hippocampal acetylcholine levels (5–10 mg/kg Bacopa extract administered to animal models of Alzheimer disease),and modulation of cholinergic neuron densities (Bacopa ethanol extract: 20–80 mg/kg orally ).Such effects of Bacopa have been attributed to the saponins contained within Bacopa, most notably that of bacoside A.