Invasive fungal infections (IFI) are on the rise due to increasing numbers of immunosuppressed and
critically ill patients. A malignant-looking pulmonary nodule in an immunosuppressed patient may indeed
be caused by a fungal organism. We report a patient, who was eventually diagnosed with an IFI
caused by an agent of hyalohyphomycosis, Talaromyces sp. determined via molecular methods and
succesfully treated with voriconazole.