There are consistent data showing that Orlistat provides a modest yet significant amount of weight loss of around 3% more than diet alone in overweight and obese adults. This weight loss appears to be maintained in the medium term in patients who continue therapy. As with any therapy, some patients tend to achieve better results than others. While weight loss of greater than 5% is generally considered clinically significant and may guide patient selection for long-term treatment, the benefit of lower levels of weight loss in those with comorbidities should not be underestimated.