CR applied for 6 weeks to young mice that has been fed a high fat diet to promote obesity, and old obese rats resulted in a preferential loss of visceral adiposity, notably, mesenteric fat which was reduced in both young and old rats by about 53% resulting in improvements in insulin sensitivity in both groups – but more so in the younger animals. These data indicated a key role played by VF in the etiology of age related insulin resistance which could be reversed because of the disproportionate effects of CR on VF