Environmental pollution by cadmium has been discovered in Mae Sot District, Tak Province, Northwestern Thailand in the years 1998-2001. The results showed the concentration of cadmium in soil samples from the field. The value is in the range 3.4 to 284 mg / kg. The samples for quality grain from the fields. Cadmium contamination was found 0.1 to 44 mg / kg., height above average cadmium in rice of Thailand. Such contamination by 95% higher than the maximum allow of CODEX Committee on Food Additives and Contaminants (CCFAC) which is defined at 0.2 mg/kg.(Department of primary industries and Mine, 2547). Contaminated with high concentrations of contaminant levels are dangerous, causing Itai-Itai disease(suwannachote, 2009). From the above cadmium contamination in the environment is a problem for farmers, Because it have contaminated in agricultural areas. By agricultural crops contaminated with quality weaken and farmers cannot use area cultivation. Including affect health. Cadmium is highly effective at keeping people in the area are vulnerable to disease, Itai - Itai. Cadmium can enter the body through skin contact and inhalation. The clinical course of all Itai–itai disease patients and persons requiring observation was examined as the research project conducted by the Research Committee for Itai–itai Disease organized by the Japan Environment Agency from 1989. The clinical course of 13 cases showed that renal tubular dysfunction had deteriorated culminating in end-stage renal failure. After the serum creatinine exceeded 2.5 mg/dl death ensued in 3–4 years (Kasuya, 1999). Impairment in renal tubular function, generalized osteomalacia and osteoporosis with the resultant multiple bone fractures are predominant clinical signs of the Itai-itai disease patients who were chronically exposed to extremely high levels of cadmium in their staple food (rice) as a result of environmental pollution by cadmium.