In mitochondrial myopathies with respiratory chain deficiency impairment of energy cell production may lead to in excess reactive
oxygen species generation with consequent oxidative stress and cell damage. Aerobic training has been showed to increase muscle
performance in patients with mitochondrial myopathies. Aim of this study has been to evaluate, in 7 patients (6F e 1 M, mean age
44.9 ± 12.1 years) affected by mitochondrial disease, concomitantly to lactate exercise curve, the occurrence of oxidative stress, as
indicated by circulating levels of lipoperoxides, in rest condition and as effect of exercise, and also, to verify if an aerobic training
program is able to modify, in these patients, ox-redox balance efficiency. At rest and before training blood level of lipoperoxides was
382.4 ± 37.8 AU, compared to controls (318.7 ± 63.8; P < 0.05), this corresponding to a moderate oxidative stress degree according
to the adopted scale. During incremental exercise blood level of lipoperoxides did not increase, but maintained significantly higher
compared to controls. After an aerobic training of 10 weeks the blood level of lipoperoxides decreased by 13.7% at rest (P < 0.01)
and 10.4%, 8.6% and 8.5% respectively at the corresponding times during the exercise test (P = 0.06). These data indicate that, in
mitochondrial patients, oxidative stress occurs and that an aerobic training is useful in partially reverting this condition.
2012 Elsevier B.V. All rights reserved.