The present research article contains a valuable confirmation in reference to bubaline SCM. From nutritionist view point, increased bacteriological load not only makes SCM milk unfit for human consumption but also alters the trace minerals concentration and amends the food value of SCM milk. Moreover, SCM influences milk enzyme activity. From the current study it is evident that there is not a single indicator; instead we need an array of indicators to detect SCM. Although, ALP and Zn were found to be indicators of SCM (former being better and more reliable in the present study as ALP showed the highest agreement amongst all with IDF criteria of SCM diagnosis for all types of mastitis causing bacterial agents) it is recommended that they both to be considered together for screening large herds for SCM. In regions like the tropics, where Gram positive bacteria are prevalent, LDH, Co and Fe can also be incorporated in the screening programs if estimating ALP and Zn is not feasible. The threshold value for ALP and Zn is fixed at 811.12 U/L and 6.01 ppm, respectively. Standardizing easy biochemical methods or qualitative tests for estimating these indicators is recommended to develop kit for diagnosing SCM in the field. An attempt to develop a pathophysiological explanation of the ascertained association is also recommended for further study.