Acne vulgaris is a common skin disorder, affecting virtually all adolescents and adults at some time in their lives. Although the overall health is not impaired, acne is not a trivial disease, as it can produce cutaneous and emotional scars that last a lifetime.1-3 Numerous psychological problems stem from acne, some even resulting in decreased employability in adulthood.4
The etiology of acne is multifactorial and according to the severity of inflammation, acne is classified into purely comedonal (non-inflammatory acne), mildly papular, scarring papular and scarring nodular acne. Clinically, the peak incidence of acne is evident during the teen
1
years, but a significant chunk of men and women between 20-40 years of age also suffer from acne vulgaris.5,6
Topical therapy is recommended for the management of acne vulgaris, especially for patients with non-inflammatory comedones and mild to moderate inflammatory acne. Comedolytic and anti-inflammatory agents along with antimicrobials are generally preferred in topical treatment of acne. But, the available drugs used for topical and systemic management of acne, have been shown to be associated with specific limitations. For example, topical application of tretinoin leads to dermal adverse reactions (erythema, peeling and burning of the skin). During the past few decades many reports have documented an emergence of antibiotic resistance by Propionibacterium acnes during the treatment of acne7-9 and systemic antimicrobials have been causally associated with various short- and long-term adverse effects).10
“Acne-N-Pimple Cream” is a polyherbal formulation recommended for the management of acne vulgaris and it contains the powders of Lenus culinaris and Alum, with extracts of Salmalia malabarica, Vitex negundo and Aloe barbadensis. The present study was planned to evaluate the efficacy and safety of “Acne-N-Pimple Cream” in the management of acne vulgaris.
Acne vulgaris is a common skin disorder, affecting virtually all adolescents and adults at some time in their lives. Although the overall health is not impaired, acne is not a trivial disease, as it can produce cutaneous and emotional scars that last a lifetime.1-3 Numerous psychological problems stem from acne, some even resulting in decreased employability in adulthood.4The etiology of acne is multifactorial and according to the severity of inflammation, acne is classified into purely comedonal (non-inflammatory acne), mildly papular, scarring papular and scarring nodular acne. Clinically, the peak incidence of acne is evident during the teen1years, but a significant chunk of men and women between 20-40 years of age also suffer from acne vulgaris.5,6Topical therapy is recommended for the management of acne vulgaris, especially for patients with non-inflammatory comedones and mild to moderate inflammatory acne. Comedolytic and anti-inflammatory agents along with antimicrobials are generally preferred in topical treatment of acne. But, the available drugs used for topical and systemic management of acne, have been shown to be associated with specific limitations. For example, topical application of tretinoin leads to dermal adverse reactions (erythema, peeling and burning of the skin). During the past few decades many reports have documented an emergence of antibiotic resistance by Propionibacterium acnes during the treatment of acne7-9 and systemic antimicrobials have been causally associated with various short- and long-term adverse effects).10กำหนด polyherbal ที่แนะนำสำหรับการจัดการของ vulgaris สิวเป็น "สิว-N-สิวครีม" และประกอบด้วยผง Lenus culinaris และสารส้ม ด้วยสารสกัดจาก Salmalia เคยลัก negundo ไม้ และ Aloe barbadensis การศึกษาปัจจุบันมีการวางแผนการประเมินประสิทธิภาพและความปลอดภัยของ "ครีมสิว-N-สิว" จัดการ vulgaris สิว
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