High fat diet group showed a high significant increase (P < .001) in feed intake, body weight and body mass index. HFD showed a significant increasing in Nor Epinephrine, Dopamine, BCHE, Homocysteine and malondialdehyde contents in brain. In testes high fat diet increased malonaldehyde contents of testes. An improvement by the treatments with Orlistat and herbal mixture was observed. Histopathological examination of brain and testes sections of high fat diet rats supported the previous biochemical results.