The main features that make CNCs attractive as a reinforcement material in polymers are their large surface area, high mechanical strength, high aspect ratio, hydrophilicity, non-toxicity, low bulk density, biocompatibility, and biodegradability (Dufresne, 2003). Despite much researches on cellulose based hydrogels for different applications, the use of CNC as reinforced materials in hydrogels from gelatin for drug delivery system has not been reported previously.