In addition, there was a decline in the expression of Bcl-2,
which would act to enhance the release of internal Ca2þ [42]. By
contrast, Individuals heterozygous for the KL-VS genetic variant
were found to have enhanced cognition and this was associated
with increased serum levels of Klotho [70].
Klotho acts to regulate the communication between neurons
and oligodendrites during myelin formation and may thus have
important implications for understanding multiple sclerosis
[71].