Given the high consumption of B. rotunda and the fact that its safety has not been scientifically established, recent studies have been focused on investigating the acute toxicity of several extracts in vivo to determine the safety of this plant for consumption. Saraithong et al. [40] demonstrated that the ethanolic extract of B. rotunda was safe for consumption as in vivo studies showed no significant changes in the body weight of B. rotunda fed rats. Furthermore, all haematological and histopathological parameters used to evaluate the toxicity effect did not show any adverse changes [40]. Meanwhile, Charoensin et al. [41] reported that two bioactive compounds from B. rotunda, pinostrobin and pinocembrin, exhibited no mutagenic effect or toxicity towards Wister rats, further confirming the safety of its consumption [41].