We found that maternal exposure to increased concentrations of PM10 was associated with multiple congenital heart defects (adjustedOR1.05,95%CI:1.01to1.10for10 μg/m3 increment). An inverse association was observed between concentrations of PM2.5 and isolated patent ductus arteriosus (adjusted OR 0.78,95%CI:0.68to0.91for5 mg/m3 increment). Sensitivity analyses showed that results were consistent.