RRT is a particular case of ‘acquired’ changes in the
clearance of drugs. The use of RRT associated with AKI and
CKD was 15 per million children in the US in 2008 [116].
Drugs can be removed during RRT by diffusion (hemodialysis)
or convection (hemofiltration). Molecular
weight and size, protein binding, volume of distribution and
electrostatic charge are key characteristics affecting drug
dialyzability