Silk fibers from silkworms have been used in textiles production and as biomedical suture material for centuries. The excellent properties of this fi ber are attractive for other applications. More recent studies suggest that the silk fi broin exhibit additional rationale for designing various forms. Additionally, silk fi bers have comparable biocompatibility with other commonly used biomaterials to tailor for specifi c applications in both of structural and biological functions. This helps to apply silk in different fi elds like cosmetics, food and drink additives, antibacterial coating or supplementary devices. To date, silk is gradually focused to address as biomaterial for tissue engineering as well as drug delivery system applications.