Acne is a chronic inflammatory disease of the
pilosebaceous unit that affects almost all teenagers
between the ages of 15 and 17 years.1 Clinical
features include oily skin, noninflammatory lesions (open
and closed comedones), inflammatory lesions (papules
and pustules), and various degrees of scarring. Increased
sebum production under androgen control, alteration of
the keratinization, follicular colonization by
Propionibacterium acnes, and inflammation are four
main processes in the pathogenesis of the disease.
Different treatments of acne offer different modes of
action, but aim to target the four aspects of acne pathology.
Topical therapies, such as benzoyl peroxide (BP),
retinoids, antibiotics with alcohol-based preparations, and
salicylic acid (SA), can cause skin irritation resulting in a
lack of patient adherence. Similarly, oral isotretinoin,
which is the most effective medication for acne, usually
causes dry skin, cheilitis, and photosensitivity.1 Dryness
Acne is a chronic inflammatory disease of thepilosebaceous unit that affects almost all teenagersbetween the ages of 15 and 17 years.1 Clinicalfeatures include oily skin, noninflammatory lesions (openand closed comedones), inflammatory lesions (papulesand pustules), and various degrees of scarring. Increasedsebum production under androgen control, alteration ofthe keratinization, follicular colonization byPropionibacterium acnes, and inflammation are fourmain processes in the pathogenesis of the disease.Different treatments of acne offer different modes ofaction, but aim to target the four aspects of acne pathology.Topical therapies, such as benzoyl peroxide (BP),retinoids, antibiotics with alcohol-based preparations, andsalicylic acid (SA), can cause skin irritation resulting in alack of patient adherence. Similarly, oral isotretinoin,which is the most effective medication for acne, usuallycauses dry skin, cheilitis, and photosensitivity.1 Dryness
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