Improving periconceptional folate state reduces the of neonatal neural defects. Therefore,incrreased folate intake is recommended before and during the early stages of pregnancy through folic acid supplements or fortifed food.
Folates also have a role in prevention of other diseases such as Cardiovascular,Canners,Alzheimer[1].Folateexist in a variety of forms related to the parent compound folic acid (pteroylglutamic acid,PGA)and each possesses different biological activity.