Selectins cause the initial rotation of leukocytes across the endothelial.
ICAM-1 serves an important role in the leukocyte movement and adhesion along
the endothelial, and an inflammatory condition increases the molecules (Gearing
& Newman, 1993). The adhesion of circulating leukocytes to vascular endothelial
cells and their migration into the subendothelial spaces are among the main
developmental processes of atherosclerosis (Albelda, Smith, & Ward, 1994). It is
also confirmed that chronic endothelial activation often shows its dysfunction,
which plays an integral role in the incidence of atherosclerosis and cardiovascular
diseases (Ross, 1999).