Other deviations between model predictions and empirical values may be due to variation in blood parameters, especially in neutral lipid content of blood, and due to differences in experimental techniques between studies. Although inter species differences in blood composition are relatively small (Nelson 1972, 1967), partition coefficients have been found to vary with changes in hematocrit and blood lipids (Fiserova-Bergerova and Diaz, 1986; Lin et al., 2002). There is considerable variation in reported blood–air partition coefficients of a chemical between studies as indicated by 90% confidence intervals in Fig. 1. Differences in experimental techniques, for example differences in equilibration time may also contribute to the observed variability in empirical blood–air partition coefficients (Wiester et al., 2002).
Other deviations between model predictions and empirical values may be due to variation in blood parameters, especially in neutral lipid content of blood, and due to differences in experimental techniques between studies. Although inter species differences in blood composition are relatively small (Nelson 1972, 1967), partition coefficients have been found to vary with changes in hematocrit and blood lipids (Fiserova-Bergerova and Diaz, 1986; Lin et al., 2002). There is considerable variation in reported blood–air partition coefficients of a chemical between studies as indicated by 90% confidence intervals in Fig. 1. Differences in experimental techniques, for example differences in equilibration time may also contribute to the observed variability in empirical blood–air partition coefficients (Wiester et al., 2002).
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