Arthritis was induced in rats as described previously [17].
Collagen Type II from the bovine nasal septum was dissolved in
0.05 M acetic acid at a concentration of 2 mg/ml and emulsified
with an equal volume of Complete Freund’s Adjuvant (CFA) containing
1 mg/ml Mycobacterium tuberculosis H37 RA and stored
on ice before use. Rats were immunized intradermally at about
1.5 cm distal from the base of the tail.