Alpha-lipoic acid (LA) and its reduced form,
dihydrolipoic acid (DHLA), have received widespread
attention as antioxidants with both preventative and
therapeutic uses in humans and laboratory animals. LA is an
antioxidant and exogenously supplied LA can be NADH
and NADPH-dependently reduced in mitochondria and
cytosol (Haramaki et al., 1997). LA has been shown to act