Therefore, TLC method development is the real demand for these drugs due to explosion of population in developing countries, where TLC suits well as an ideal technique (inexpensive).The monitoring of analytes in plasma needs sample preparation before loading onto TLC. It has been observed that about 80 percent chromatographers are using solid phase extraction (SPE) as the versatile method of sample preparation for plasma (Ali et al., 2008). It is interesting to observe that no method is available for monitoring these drugs in plasma by using SPE–TLC combination, that we found ideal for third world countries. In view of these facts, attempts have been made to develop inexpensive, fast, selective and reproducible SPE–TLC methods for analyses of the reported contraceptives in human plasma. Based on the results obtained and modelling, efforts were made to explain the interactions of these drugs with progesterone receptor protein for further research. The results of these findings are discussed herein.