Diagnosis is made by evidence of microangiopathic
hemolytic anemia (anemia, thrombocytopenia,
and schistocytes/helmet cells seen on blood smear)
with some evidence of renal insufficiency. Although
the hemolytic anemia may be severe, it does not typically
correlate with the severity of renal disease. In typical
HUS, a stool culture may be obtained to isolate the
most common causes of HUS. E. coli O157:H7 should
be cultured using MacConkey agar because this particular
strain does not ferment sorbitol. Leukocyto