Ion channelsplaycrucialroles in the cellularresponse to signalsandchangesin the extracellularenvironmentbycontrolling
ion homeostasisandmembraneexcitability.Theirproperfunctioning criticallydependsonthefinetuningoftheirlocalization atcell
surface.Thisprocessisdictatedbythesecretoryandendocyticvesiculartraffickingpathwaysthatofteninvolvedynamicinteractionsbetweendistinctsequencesignalsonthecargosandcellulartransport
machineries.Manyimportantdiscoveriesontraffickingsignalshave
comefromthestudiesonionchannelsincludingK
+
channels.Forinstance,theArg-based(‘RXR’)endoplasmicreticulum(ER)retention/