The increasing complexity of surgical procedures and instruments and the continuing transition of surgical and other invasive procedures from inpatient to ambulatory venues can increase patient infection risk. In supporting clinical teams in attaining the lowest possible number of postsurgical and postprocedural infections, IPs must be well informed regarding which surgical and nonsurgical invasive procedures are performed in their OR and ambulatory departments. Collaboration between IPs and the perioperative and SP departments, as well as the numerous other departments where surgical and invasive procedures are performed, can support optimized infection prevention practices. Additionally, as evidence evolves, IPs can assist teams in considering expanding infection prevention bundles to include new products and practices.