membranes of microorganisms. It indirectly affects the
enzymatic function of dehydrogenase and adenosine
triphosphatase present in the cell wall of bacteria resulting
in the disruption of cell membrane.[16] It is evident in this
study that the chlorhexidine showed a definite reduction
in the microbial activity and an increase in the pH and
buffering capacity resulting in marked anticariogenic
effect. However, there is a lack of convincing clinical data
and long-term clinical evidence for caries prevention with
chlorhexidine.[5] Moreover, chlorhexidine have reports of
causing discoloration effects[17] and an unpleasant taste.[18]