Skin prick testing (SPT) provides information about the presence of specific IgE to protein and peptide antigens (allergens). Correctly used, the skin prick test has good sensitivity and specificity for the presence of allergen-specific IgE and is in some cases more sensitive than in-vitro testing for specific IgE in serum6,7. The discomfort is small and the risk of systemic reactions is minimal although not negligible. Ultimately the integration of skin prick test results, knowledge of the biology of the various allergens and the exposures of the patient, and the nature and timing of the symptoms enable the construction of a diagnosis and an appropriate management plan for the patient.