Normally, the cell cycle is precisely controlled by cell cycle checkpoint,
which ensures the fidelity of cell division in eukaryotic cells. However,
cell cycle arrest triggered by various exogenous and endogenous stimulating factors could result in the breakdown of cell division, cell
death and/or apoptosis. In present study, germacrone treatment induced
G0/G1 and G2/M phase arrests in the cell cycle progression, indicating
an other possible mechanism by which germacrone inhibits the
proliferation of breast cancer cells