Lurasidone may exert antidepressant effects by increasing dopamine activity in the prefrontal cortex through activity at 5-HT2A and 5-HT1A receptors. It may enhance serotonin activity by downregulating 5-HT2A receptors. In addition, it may increase norepinephrine by
antagonizing alpha1 receptors. Antagonism of 5-HT7 receptors may improve mood