Abstract
Objective.
The objective of this study was to observe the effects of magnesium sulfate on various blood biochemical
parameters and coagulation status of patients with preeclampsia.
Methods.
During a period of 4 years, 50 patients with severe or mild preeclampsia progressing to severe preeclampsia were
included in the cross-sectional study. Prothrombine (PT), activated limited thromboplastin time (aPTT), magnesium level,
biochemistry parameters, systolic, and diastolic blood pressure (BP) were measured. These parameters were remeasured in
the second hour of magnesium sulfate treatment.
Results.
After magnesium sulfate therapy; creatinine levels are decreased (
p
5
0.05), bleeding time is increased and serum
magnesium levels are increased (
p
5
0.01), systolic and diastolic BP values decreased significantly (
p
5
0.01). PT, aPTT,
platelet levels, and coagulation time did not change after treatment.
Conclusion.
Magnesium sulfate infusion prolonged bleeding time in patients with severe preeclampsia. This is clinically
important because it worsens the present condition and causes possible complications