The control of melon wilt caused Fusarium oxysporum f. sp. melonis (Fom) has become a complex problem
for melon (Cucumis melo L.) growers worldwide. In this study, we evaluated the ability of Trichoderma
spp. to control melon wilt under field conditions, and the application of liquid compost as a foodbased
strategy to improve the biocontrol efficiency of the selected strain. In a first experiment, we evaluated
the use of Trichoderma harzianum LCB47, Trichoderma viride LCB48, Trichoderma koningii LCB49, and
Trichoderma polysporum LCB50 to control melon wilt in a naturally infested soil. The treatment with T.
polysporum LCB50 (Tp) showed the highest efficiency to control melon wilt (44.85%), increasing the fruit
yield in 43%. In the second experiment, Tp was applied as seed treatment, and repeated once at 15 days
after transplanting. Two doses of liquid compost: 25 (LC25) and 50 mL pL1 (LC50), were applied by fertigation
on a weekly basis along the crop development. In this experiment, T. polysporum LCB50 applied
alone resulted in a significant (P < 0.05) control of wilt (32.2%), and 27% increase in fruit production.
Single application of both doses of LC did not significantly reduced disease incidence. However, a strong
synergistic effect was observed applying Tp and LC25 and LC50, resulting in a highly significant wilt control
(68 and 72%, respectively) and an increase in productivity. The use of Tp + LC50 treatment increased
in 100% the production of commercial fruits. From the results, a strategy based on the use of T. polysporum
LCB50 and an organic matter source is proposed for the integrated management for melon wilt