The treatment strategy for PPHN is aimed at maintaining adequate systemic blood pressure, decreasing pulmonary vascular resistance, ensuring oxygen release to tissues, and minimizing lesions induced by high levels of inspired oxygen and ventilator high pressure settings.
General management principles include the following:
Continuous monitoring of oxygenation, blood pressure, and perfusion
Maintaining a normal body temperature
Correction of electrolytes/glucose abnormalities and metabolic acidosis
Nutritional support
Minimal stimulation/handling of the newborn
Minimal use of invasive procedures (eg, suctioning)