Increased concentrations of HA in serum are associated with several inflammatory skin diseases, such as psoriasis [33, 34], progressive systemic splerosis [35-37] and dermatomyositis [38]. Furthermore, elevated concentrations ofHA in suction blister fluid [39] were found in blisters raised on psoriatic lesions. Histochemical staining showed high expression ofICAM-l, especially close to the vessels in psoriatic skin [1 ~].