synthetic cannabinoids. Though cannabinoids
are clinically used for anti-palliative effects, recent studies open a promising
possibility as anti-cancer agents. They have been shown to possess anti-proliferative
and anti-angiogenic effects in vitro as well as in vivo in different cancer models.
Cannabinoids regulate key cell signaling pathways that are involved in cell survival,
invasion, angiogenesis, metastasis, etc. There is more focus on CB1 and CB2, the two
cannabinoid receptors which are activated by most of the cannabinoids. In this review
article, we will focus on a broad range of cannabinoids, their receptor dependent and
receptor independent functional roles against various cancer types with respect to
growth, metastasis, energy metabolism, immune environment, stemness and future
perspectives in exploring new possible therapeutic opportunities.