In a long-term study, alloxan-induced diabetic mice were treated with MCP and Xiaoke pill, respectively, once a day, for 28days. The anti-hyperglycemic effect of repeated oral administra-tion of MCP on the BGL in diabetic mice is shown in Fig. 2. The various BGL of severely diabetic mice were estimated before and after 7, 14 and 28 days of treatment. Seven days after alloxanadministration, blood glucose values were 3–5 folds higher in all the groups in comparison to normal control (Group I) and were not statistically (P > 0.05) different from each other. The blood glucose concentration had been kept in high level among16–22 mmol/L in diabetic control group (Group IV) throughout thewhole experiment periods. But the blood glucose in the MCP groupslowered significantly, especially that in the MCP groups at 200 and 300 mg/kg. The BGL decreased by 55.76% and 57.28% in the animalstreated with MCP-M and MCP-H respectively, after 28 days of treat-ment (Fig. 2). In the positive control (Group V), reduction of BGL was also significant (P < 0.05) from 28 days after administration.