The
preservation of much of the Greco-Roman expertise during
the Dark and Middle Ages (5th-12th centuries) may be
attributed to the Arabs, who expanded it to include the use a stereoisomer of epipodophyllotoxin, the
precursor to the semisynthetic anti-cancer agent, etoposide
(4; Scheme 1) (section 5.2). A long history of medicinal use,
including the treatment of skin cancers and warts, led to the
investigation of Podophyllum peltatum Linnaeus (commonly
known as the American mandrake or Mayapple), resulting
in the isolation of podophyllotoxin as the active agent from
the roots.
The
preservation of much of the Greco-Roman expertise during
the Dark and Middle Ages (5th-12th centuries) may be
attributed to the Arabs, who expanded it to include the use a stereoisomer of epipodophyllotoxin, the
precursor to the semisynthetic anti-cancer agent, etoposide
(4; Scheme 1) (section 5.2). A long history of medicinal use,
including the treatment of skin cancers and warts, led to the
investigation of Podophyllum peltatum Linnaeus (commonly
known as the American mandrake or Mayapple), resulting
in the isolation of podophyllotoxin as the active agent from
the roots.
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