Sorghum (Sorghum bicolor L.) is a gluten-free cereal that has the highest content of phenolic compounds
among cereals. It needs to be processed prior to use for human consumption, which may change its
antioxidant profile. The knowledge on the effects of extrusion and dry heat in a conventional oven on
flavones, flavanones, and proanthocyanidins is limited. Thus, the content and stability to dry heat in a
conventional oven (DHCO) and extrusion cooking on phenolic compounds profile in sorghum genotypes
were evaluated. Flavanones and flavones decreased after extrusion cooking (100%) and DHCO (31.7
e61.6%). The 3-deoxyanthocyanidins were stable in DHCO but were susceptible to extrusion cooking
(70.7e93.9%). Proanthocyanidins were identified only in the genotype SC391 and were reduced after
both treatments (DHCO: 39.2% and extrusion cooking: 52.1%). Phenols decreased in the genotype SC319
submitted to DHCO (8.3%) and in all extruded genotypes (13.6e14.9%). The DHCO increased the antioxidant
capacity in all genotypes, whereas extrusion cooking reduced antioxidant capacity in only two
genotypes. In general, differential stability of the major flavonoids in sorghumwas observed under DHCO
and extrusion cooking, implying that different processing techniques can be selected to minimize losses
of bioactive polyphenols in sorghum depending on the flavonoid composition.