Hybridization of DNA is accomplished by heating strands of DNA from two different species to 86° C [186.8° F].
This breaks the hydrogen bonds between all complementary base pairs.
The result is many single-stranded segments of DNA.
The single-stranded DNA from both species is mixed together and allowed to slowly cool.
Similar strands of DNA from both species will begin to chemically join together or re-anneal at complementary base pairs by reforming hydrogen bonds.