The observed disease in marmosets seems to recapitulate the
documented disease progression in severe MERS cases more closely
than rhesus macaques, which appear to model the mild to
moderate, transient MERS cases. The marmoset is a severe disease
model, whereas the rhesus macaque model is transient.
Furthermore, certain hallmarks of severe disease observed in
humans, such as consolidation of the lungs and changes in blood
chemistry indicative of liver or kidney failure, are reproduced in
the marmoset model. The evaluation of antivirals and vaccines
might therefore be more predictive in marmosets than in rhesus
macaques. However, the relatively small size of the marmoset limits
the number of samples that can be taken and consequently the
data obtained within an experiment. Both models provide important
insights into the MERS-CoV infection mechanism and disease
progression, and further development is desirable
The observed disease in marmosets seems to recapitulate thedocumented disease progression in severe MERS cases more closelythan rhesus macaques, which appear to model the mild tomoderate, transient MERS cases. The marmoset is a severe diseasemodel, whereas the rhesus macaque model is transient.Furthermore, certain hallmarks of severe disease observed inhumans, such as consolidation of the lungs and changes in bloodchemistry indicative of liver or kidney failure, are reproduced inthe marmoset model. The evaluation of antivirals and vaccinesmight therefore be more predictive in marmosets than in rhesusmacaques. However, the relatively small size of the marmoset limitsthe number of samples that can be taken and consequently thedata obtained within an experiment. Both models provide importantinsights into the MERS-CoV infection mechanism and diseaseprogression, and further development is desirable
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